Edit this page
Modify this page
Edit this string
         
You are here: Home >Health >Risks for your health >
Western diet of processed foods found to cause chronic liver inflammation

 

There are many lifestyle and dietary factors than can lead to chronic liver inflammation, and one of them is a Western diet. According to a new study, this particular diet, which is rich in saturated fats and refined sugars, can increase the chances of developing hepatic inflammation, especially among males. If left untreated, the condition may progress into more advanced liver diseases such as cancer.

Led by Professor Yu-Jui Yvonne Wan, vice chair of the Department of Pathology and Laboratory Medicine at UC Davis Health, researchers utilized a farnesoid x receptor- or FXR-deficient mouse model for their study. FXR is also known as bile acid receptor (BAR) and plays an important role in the homeostasis of bile acids, glucose, and lipids. Patients with liver cancer or cirrhosis, the irreversible scarring of the liver, typically have low FXR levels, hence the importance of this mouse model in understanding the impact of diet and inflammation on the development of liver diseases.

The FXR-deficient mice, as well as wild mice, were put on either a Western diet or a matching control diet over the course of 10 months. Broad-spectrum antibiotics were included as well to analyze their effects on gut microbiota, and subsequently on liver inflammation.

Because the liver receives 70 percent of its blood supply from the intestine, it is important to understand how the gut contributes to liver disease development,” Wan explained. “Our data show that diet, gender, and different antibiotic treatments alter the gut microbiota as well as bile acid profile and have different effects on liver inflammation.
By the end of the study, the researchers discovered similarities between FXR deficiency and Western diet intake.

Both Western diet-fed wild mice and control diet-fed FXR-deficient mice accumulated fat in their livers, a development that was more severe in the male mice. Additionally, wild mice that had been given a cocktail of ampicillin, vancomycin, neomycin, and metronidazole displayed few signs of liver inflammation. The same could not be said for the FXR-deficient mice that were fed a Western diet, however.

The researchers found that pro-inflammatory Proteobacteria and Bacteroidetes continued on even after the mice were given broad-spectrum antibiotics. Conversely, the Western diet-fed mice that were given pro-Firmicutes antibiotics had experienced decreased liver inflammation.

Gut and liver health are linked. It is clear that microbial imbalance and dysregulated bile acid synthesis are inseparable, and they jointly contribute to hepatic inflammation via the gut-liver axis,” stated Wan. “Our results suggest that probiotics and FXR agonists hold promise for the prevention and treatment of hepatic inflammation and progression into advanced liver diseases such as cancer.”

Thus, the detrimental effects of Western diet on the liver may partly lie in the diet decreasing the amount of anti-inflammatory, friendly gut bacteria while simultaneously encouraging the growth of pro-inflammatory gut bacteria.
In fact, a 2013 study found that one way that friendly gut bacteria protects the liver is by preventing the uptake of lipopolysaccharides into the intestines. As a result of this, the liver is relieved of irritation and stress, as lipopolysaccharides are bacterial toxins that have been linked to obesity.

 

yogaesoteric
October 26, 2017

 

Articles published recently

> 16 OctoberNearly 1/3 of Early Deaths Could Be Prevented by Giving Up Meat, Says Harvard

> 16 OctoberThese 11 Essential Oils Will Help With Your Lucid Dreaming

> 15 OctoberStudy: New herbal medication effectively reduces arthritis symptoms

> 15 OctoberYour Body Was Created to Overcome Cancer

> 14 OctoberStudy documents the remarkable antitumor activity of the wild carrot

> 14 OctoberWhy Were Vatican And Church Hierarchies not Unnerved About Infertility “Ingredients” In WHO’s African Tetanus Vaccine Campaign?

> 13 OctoberWhat You Don’t Know About Sugar Can Kill You

> 11 OctoberWould You Go Vegan To Save The World? New Study Suggests It’s The Best Option

> 10 OctoberWhat you need to know before you begin a water-only fast

> 10 OctoberHow to increase the absorption of turmeric by 1,000 percent or more

> 9 October10 Ways to Boost Serotonin Levels without Medication

> 9 OctoberThe Damaging Effects of 5G Wireless on Your Health

> 8 OctoberDNA vaccines and the permanent alteration of human genetics

> 8 OctoberAloe Vera: Egyptians Called it the Plant Of Immortality and Here’s What It Does to your body!

> 7 OctoberStudy: The Time You Wake Up Could Impact Mental Health

> 7 OctoberNanoparticles in Tea Kills Lung Cancer Cells, Study Says

> 7 OctoberHow Sugar Keeps You Trapped In a Cycle of Addiction

> 5 OctoberPeaches: The health benefits of the sweet and sour fruit

> 4 OctoberKnowledge on heavy metals, pesticides, vaccines and more

> 3 OctoberDoctors recommend plant-based diets for better health

> 3 October8 Health Benefits of Spelt