Micro blood clots: key to explaining covid harm (II)

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Long covid has clot cause

Now we come to the third area of medical research that has also found micro clots as the likely cause of that is being called “long” covid; which refers to people who seem to have successfully recovered from covid but live with serious residual health problems that are related to their previous covid infection. Sadly, some doctors have said these persistent health problems are psychological in nature. Here some new research is summarized and shows that the cause of persistent health problems in covid patients are the micro blood clots.

The material in this article was originally published in the journal Cardiovascular Diabetology in August 2021, titled “Inflammatory micro clots in blood of persons suffering from long covid.” The research was done at Stellenbosch University in South Africa. Researchers found an overload of various inflammatory molecules, ‘trapped’ inside insoluble microscopic blood clots (micro clots), in the blood of persons suffering from lingering symptoms experienced by patients with long covid.

This important finding was made by Prof. Resia Pretorius, a researcher in the Department of Physiological Science at Stellenbosch University. She started looking at micro clots and their molecular content in blood samples from patients with long covid. The findings have since been peer-reviewed and published in the journal. “We found high levels of various inflammatory molecules trapped in micro clots present in the blood of patients with long covid. Some of the trapped molecules contain clotting proteins such as fibrinogen, as well as alpha(2)-antiplasmin,” Prof. Pretorius explained.

Alpha(2)-antiplasmin is a molecule that prevents the breakdown of blood clots, while fibrinogen is the main clotting protein. Under normal conditions the body’s plasmin-antiplasmin system maintains a fine balance between blood clotting (the process by which blood coagulate to prevent blood loss after an injury) and fibrinolysis (the process of breaking down the fibrin in the coagulated blood to prevent blood clots from forming). With high levels of alpha(2)-antiplasmin in the blood of covid-19 patients and persons suffering from long covid, the body’s ability to break down the clots are significantly inhibited.

The insolubility of the micro clots became apparent through specific analysis of blood plasma samples from persons with acute covid and long covid; they continued to deposit insoluble pellets in collection devices.

This is the first research group to have reported on finding micro clots in the blood samples from patients with long covid, using fluorescence microscopy and proteomics analysis, thereby solving yet another puzzle associated with the disease.

“Of particular interest is the simultaneous presence of persistent anomalous micro clots and a pathological fibrinolytic system,” they write in the research paper. “This implies that the plasmin and antiplasmin balance may be central to pathologies in long covid, and provides further evidence that covid-19, and now long covid, have significant cardiovascular and clotting pathologies.”

In other words, this research connects with what has been found in covid patients with micro blood clots.

To date they have collected blood from one hundred long covid persons who participated in the long covid registry which launched in May 2021, as well as from 30 healthy persons.

The Guardian article

This research was seen as a very important development in a January 2022 article in The Guardian with the heading “Could microclots help explain the mystery of long covid?” It was written by Resia Pretorius, one of the senior South African researchers. “My lab has found significant microclot formation in long covid patients. Unfortunately, these are missed in routine blood tests.”

Here are more excerpts from this article that was aimed at informing the world about the importance of micro clots:

“One of the biggest failures during the covid-19 pandemic is our slow response in diagnosing and treating long covid. As many as 100 million people worldwide already suffer from long covid. That staggering number will eventually be much higher, if we take into account that diagnoses are still inadequate, and that we still do not know what the impact of Omicron and future variants will be.”

“Patients with long covid complain of numerous symptoms, the main ones being recurring fatigue and brain fog, muscle weakness, being out of breath and having low oxygen levels, sleep difficulties and anxiety or depression. Some patients are so sick that they cannot work or even walk a few steps. There is possibly also an elevated risk of stroke and heart attacks. One of the biggest sources of concern is that even mild and sometimes asymptomatic initial covid-19 infection may lead to debilitating, long-term disability.” [That last sentence is especially important.]

“Since early 2020, we and other researchers have pointed out that acute covid-19 is not only a lung disease, but actually significantly affects the vascular (blood flow) and coagulation (blood clotting) systems.”

“In blood from patients with long covid, persistent microclots are resistant to the body’s own fibrinolytic processes. We found high levels of various inflammatory molecules trapped in the persistent microclots, including clotting proteins like plasminogen, fibrinogen and Von Willebrand factor (VWF), and also Alpha-2 antiplasmin (a molecule that prevents the breakdown of microclots).”

“The presence of persistent microclots and hyperactivated platelets (also involved in clotting) perpetuates coagulation and vascular pathology, resulting in cells not getting enough oxygen in the tissues to sustain bodily functions (known as cellular hypoxia). Widespread hypoxia may be central to the numerous reported debilitating symptoms.”

And here is what long covid victims need to know: “So why can long covid patients not go to their nearest clinic or health care practitioner to find treatment options? Currently there are no general pathology tests readily available to diagnose these patients. Desperately ill patients are told that their pathology test results are within normal/healthy ranges. Many are then told that their symptoms are possibly psychological and they should pursue meditation or exercise.

The main reason the traditional lab tests do not pick up any of the inflammatory molecules is that they are trapped inside the fibrinolytic-resistant microclots (visible under a fluorescence or bright-field microscope, as our research has shown). When the molecular content of the soluble part of the plasma is measured, the inflammatory molecules, including auto-antibodies, are simply missed.”

Remember that Dr. Hoffe used the d-dimer test to confirm the presence of micro blood clots, and this test can be ordered by your physician. Also, many pro-ivermectin articles invoke not merely the anti-viral property that works to address initial covid infection, but also its anti-inflammatory property more important after the initial viral replication phase.

Autopsy findings

There is also a fairly large medical literature with findings of micro blood clots from autopsies. Here is just one example published in 2020 by Dr. Amy Rapkiewicz, the chairman of the department of pathology at NYU Langone Medical Center. Describing the work in a news story was this: “The clotting was not only in the large vessels but also in the smaller vessels. And this was dramatic, because though we might have expected it in the lungs, we found it in almost every organ that we looked at in our autopsy study,” the researcher said.

This too was noted in another news story: “We knew that clinical people were finding clots in these [covid] patients,” she said. “So although I knew that that was going to be there, I didn’t expect it at the microscopic level to the degree that I saw it.” Her autopsy study found blood clots in small vessels of the patients’ lungs, hearts, kidneys and livers.

In another news story this was noted in 2020 about research at Harvard University: “Researchers also noted that patients with the novel coronavirus suffered many microscopic blood clots. In a stark difference with lungs infected with the flu, the micro-clots were nine times as present in areas of the lungs that allow the passage of oxygen into the patient’s bloodstream while carbon dioxide is emitted.”

This is from the published medical study: “Histologic analysis of pulmonary vessels in patients with covid-19 showed widespread thrombosis with microangiopathy. Alveolar capillary microthrombi were 9 times as prevalent in patients with covid-19 as in patients with influenza. In lungs from patients with covid-19, the amount of new vessel growth – predominantly through a mechanism of intussusceptive angiogenesis – was 2.7 times as high as that in the lungs from patients with influenza.” In other words, micro blood clots were uniquely associated with covid infection.

This is the title of a May 2020 medical article: “Pathophysiology of SARS-CoV-2: Targeting of endothelial cells renders a complex disease with thrombotic microangiopathy and aberrant immune response. The Mount Sinai covid-19 autopsy experience.” Here is the summary of the findings; note the word micro: “Autopsies were performed at the Mount Sinai Hospital on 67 covid-19 positive patients and data from the clinical records were obtained from the Mount Sinai Data Warehouse. The experimental design included a comprehensive microscopic examination carried out by a team of expert pathologists, along with transmission electron microscopy, immunohistochemistry.”

“We report a comprehensive autopsy series of 67 covid-19 positive patients revealing that this disease, so far conceptualized as a primarily respiratory viral illness, also causes endothelial dysfunction, a hypercoagulable state [an increased tendency to develop blood clots], and an imbalance of both the innate and adaptive immune responses. Novel findings reported here include an endothelial phenotype of ACE2 in selected organs, which correlates with clotting abnormalities and thrombotic microangiopathy, addressing the prominent coagulopathy and neuropsychiatric symptoms.

Another original observation is that of macrophage activation syndrome, with hemophagocytosis and a hemophagocytic lymphohistiocytosis-like disorder, underlying the microangiopathy [disorder involving small blood vessels]and excessive cytokine release.” In other words, this study also found evidence of micro clots in covid victims.

Lastly, is the work of Dr. Sucharit Bhakdi. He has noted: “immune and blood-related categories of risks from vaccines: (1) Clotting from the direct action of spike protein in the bloodstream; (2) Further clotting from the immune system attacking spike-producing endothelial cells.” This too was said: “The RNA injected into your body are going to enter the cells that line blood vessels.”

He points to spiny spike protein that these cells will generate and protrude outwards to attract blood platelets and form micro-clots. Days after vaccination, white blood cells known as lymphocytes as well as antibodies will begin to mount an attack against these cells. If you dare to repeat this (get the second jab), “God help you” warns Dr Bhakdi. He warned about the blood clot side-effects months before the roll-out of the mRNA vaccines.

Conclusions

An excessive formation of micro blood clots is linked to spike proteins coming from covid infection OR from anti-covid vaccines, that introduce them into the body or, respectively, cause the body to produce them.

Micro blood clots seem to be the likely cause of many millions of health impacts and deaths from covid infection as well as from covid vaccines, and even many millions of long covid victims suffering diverse health problems with no apparent medical solution.

Have you heard any government or public health official speak of cov-related micro blood clots? Probably not. But not because they are insignificant.

Now, you probably know more than them. Now you realize that it could be a scandal of enormous proportions due to the suppressing of so much information about the spike protein induced micro blood clots.

yogaesoteric
July 11, 2022