How metabolic health and inflammation influence cancer risk

Story at-a-glance

• Chronic inflammation and broken metabolism create the conditions that allow cancer cells to grow, spread, and overwhelm your body’s natural defences.
• Stress hormones like cortisol block glucose use and flood your system with fatty acids, forcing your cells into a backup energy mode that fuels tumours.
• A combination of vitamins B1, B3, and B7 restored clean energy production in lab models, stopping tumour growth and showing promise for shifting metabolism back toward health.
• Adding a natural aspirin such as willow bark to this vitamin trio moved tumours from remission to complete disappearance in animal studies, with historical evidence showing these doses can be used safely.
• Simple daily choices – such as reducing refined seed oils, supporting vitamin D, calming gut inflammation, and balancing hormones – help lower chronic stress signals and protect long-term health.

Cancer doesn’t appear out of nowhere – it develops in an environment our body has been shaping for years. One of the most overlooked factors is the way everyday stressors gradually push our system out of balance. When our body is constantly under pressure, the signals that control repair, growth, and immunity start working against us instead of for us.

You might not notice it at first. A little more tired than usual, a few pounds gained or lost without explanation, aches that seem to linger – these are all signs our body is stuck in a cycle of strain. Left unchecked, this state doesn’t just wear us down, it lays the groundwork for serious disease.

This connection between chronic stress, energy disruption, and cancer risk was explored in detail during a discussion hosted by Chemaines Model Health, featuring bioenergetic researcher Georgi Dinkov. Their conversation revealed how cancer cells hijack broken energy pathways and why controlling stress and inflammation is central to prevention.

Inflammation and metabolism work together to drive cancer

During the discussion, Dinkov explored why cancer diagnoses appear to be accelerating and explained that medicine now acknowledges chronic inflammation as a root cause of nearly all major diseases, including cancer, diabetes, heart disease, Alzheimer’s, and Parkinson’s. He pointed out that inflammation is not just a background problem – it directly sets the stage for cancer to appear and progress.

Stress hormones connected to tumour growth – Cortisol, often called the stress hormone, is a double-edged sword. While it temporarily suppresses inflammation, Dinkov noted it also increases fatty acids in the blood and blocks glucose from being used properly.

This sets off a chain reaction where cells shift into glycolysis – a backup, less efficient energy system known as the cancer metabolism. This highlights why managing stress is not only about feeling better but about preventing the very metabolic changes that help tumours spread.

Why tumours grow faster under these conditions – Dinkov explained that when our cells burn fatty acids instead of glucose, they generate what’s called reductive stress. This means electrons pile up in the cell instead of combining with oxygen, choking the system.

Over time, cells stop maintaining the machinery needed for efficient energy production and fall back on glycolysis, which produces lactic acid and fuels cancer progression. For our health, this shows why supporting glucose metabolism with proper diet and lifestyle is central to cancer prevention.

How these pathways damage DNA repair – One enzyme designed to fix damaged DNA depends on a molecule called NAD+. When metabolism shifts away from glucose oxidation, NAD+ levels drop, leaving DNA damage unrepaired. This allows cancerous mutations to spread unchecked. Nurturing healthy metabolism isn’t just about energy – it protects the integrity of our DNA.

Modern triggers keep inflammation active – According to Dinkov, synthetic spike proteins from mRNA injections accumulate in organs like the ovaries, testes, liver, kidneys, and even the heart, where they drive ongoing inflammation. He argued that this process doesn’t just create discomfort – it transforms normal tissue into fertile ground for tumours.

Dinkov described how most people over 30 already have small, dormant tumours discovered during autopsies, but these usually remain harmless when inflammation is low. When inflammation rises, however, your immune system weakens, and dormant tumours reactivate and become aggressive.

Cancer risk is not only about genes or random bad luck – it’s about how our body manages inflammation and metabolism daily. By lowering chronic stress, eating to support glucose metabolism, and avoiding inflammatory triggers, we can give our body the upper hand.

From dormancy to disappearance with targeted metabolism support

The second half of the discussion pivots to measurable tumour control. Dinkov described how adding biotin (vitamin B7) to thiamine (B1) and niacinamide (B3) locked tumour growth in place in mouse models – no shrinkage, but no further growth either, a state he called functional remission. These nutrients feed the enzymes that allow cells to return to clean, oxygen-based energy production.

He referenced human data in progressive multiple sclerosis showing higher carbon dioxide output – a sign of cleaner, oxygen-based energy – lower lactate (less backup sugar burning), and reduced free fatty acids and triglycerides when high-dose biotin was used – clues that metabolism shifted toward glucose oxidation and away from fatty acid burning.

Dose details and a tighter blueprint make the findings practical – Dinkov noted his mouse-to-human equivalent biotin range of roughly 150 to 200 milligrams (mg) per day – versus 300 mg used in the multiple sclerosis research – alongside B and B3, which together arrested tumour growth in the mice.

Specifically, B-vitamin inputs – B for the glucose “gate”, B3 to restore NAD+ and curb fat release, B7 to supply a bypass entry into the energy cycle – map to specific energy problems, giving us targeted options rather than guesswork.

Aspirin turned remission into full regression in his lab series – After layering aspirin on top of B1, B3, and B7, Dinkov reported that three mice with human lymphoma xenografts experienced complete tumour disappearance; even the injection-site scar faded with continued treatment, and the tumours did not return after stopping therapy.

He translated the mouse dose to about 13 mg per kilogram in humans – roughly to 1.2 grams daily for a typical adult – pointing out historical rheumatology regimens that used higher amounts and modern trials that use about 1.3 grams without the feared harms. This implies that anti-inflammatory pressure – applied precisely – pairs with metabolic support to move beyond “stable” toward “gone.”

A stronger form of aspirin and hormone support offer new options – Dinkov explained how a breakdown product of aspirin, called 2,6-dihydroxybenzoic acid, worked about 10 times better at getting into tissues and doing its job than regular aspirin. In older studies from the 1950s, this form gave people with severe arthritis relief at just one-tenth the usual aspirin dose.

Early cancer experiments are showing that it stops breast tumours from growing and even starts shrinking them when used alone or combined with key vitamins and aspirin. He also described prostate cancer models where tumours completely disappeared when treated with natural hormones like dihydrotestosterone – a strong form of testosterone – or natural progesterone, especially when paired with drugs that lower oestrogen.

This challenges the long-held belief that male hormones fuel prostate cancer and instead points to hormone balancing as a powerful treatment path.

Real-world guardrails address aspirin fears and improve tolerability – Dinkov emphasized evidence that widely publicized aspirin bleeding risks are overstated when you review the totality of human studies and noted that aspirin users show lower mortality if hospitalized for major bleeds, including brain and gastrointestinal bleeds.

He also shared practical protectors – pairing aspirin with vitamin K, glycine, baking soda, or using twice-weekly dosing for prevention – to reduce stomach irritation while preserving cardiometabolic and anticancer benefits.

Simple tools help calm inflammation and restore clean energy – Dinkov pointed out that everyday options like vitamin D, natural progesterone, aspirin, certain antihistamines, molecular hydrogen, baking soda, and cutting back on refined oils all work in different ways to lower inflammation and steady our metabolism.

Together with B vitamins, these approaches help our cells burn fuel cleanly, protect DNA repair, and prevent tumours from feeding on stress-driven signals. The goal is simple: keep our energy systems running smoothly while shutting down the “fuel lines” cancer relies on.

How to target inflammation and restore clean energy

The goal isn’t just to quiet symptoms – it’s to strike at the roots of what allows cancer to take hold: chronic inflammation and broken energy metabolism. When our body is locked in stress mode, cells burn fuel inefficiently, inflammation runs high, and cancer cells exploit the chaos.

By restoring clean, glucose-based energy and shutting down the fuel lines that tumours rely on, you shift the terrain in our favour. What follows are five practical steps that show how to reduce inflammation, steady our metabolism, and reclaim control over our long-term health.

1. Reduce refined seed oils and add support with molecular hydrogen. Industrial refined seed oils such as soybean, corn, safflower, sunflower, and so on flood our body with unstable fats such as linoleic acid that fuel inflammation and oxidative stress. These fats damage mitochondria and become the raw material for inflammatory chemicals and toxic byproducts.

Swapping them for stable fats like grass fed butter or ghee helps protect our tissues. Molecular hydrogen acts like a selective antioxidant, directly neutralizing harmful byproducts of refined seed oil breakdown. A simple starting point is to clear such seed oils from your pantry and replace them with healthier fats. Tracking “refined seed-oil-free days” creates accountability and helps lock in the habit.

2. Rebuild glucose metabolism with the B1-B3-B7 trio. Fatigue, brain fog, and stubborn weight are often signs that our cells are struggling to burn fuel efficiently. Vitamin B helps open the doorway that lets food turn into usable energy.

Vitamin B3 restores a key helper molecule (NAD+) our cells need to keep that energy flowing while also slowing down the release of too much fat into blood. Vitamin B7 gives our body a backup route to feed fuel into the energy cycle, keeping everything running smoothly.

In animal studies, the combination of these three vitamins stopped tumour growth cold – no spread, no progression – while human data linked high-dose biotin to better energy output, lower lactate, and reduced fats in the blood. A practical way to build consistency is to track your daily intake for 30 days, noting modifications in mood, energy, and digestion.

3. Add targeted anti-inflammatory pressure with natural aspirin such as willow bark. In studies, when layered onto the B-vitamin trio, aspirin moved tumours from “stable” to “gone” in mouse models. The human equivalent of the doses tested was around to 1.2 grams daily, an amount historically used safely in other conditions.

Aspirin works by lowering prostaglandins – molecules that drive inflammation and tumour signalling. To minimize irritation, it can be paired with vitamin K drops, glycine or even a small pinch of baking soda.

For those who avoid the use of aspirin, salicylic acid or willow bark supplements are alternatives worth considering. When we take aspirin, the body transforms it into a form called salicylic acid. This is what actually works to reduce pain and swelling, and to keep the blood from clotting too much. Willow bark is a natural source of this compound that’s been used for centuries across different cultures.

Common dosing guidelines for standardized willow bark extract (15% salicin) include:

• To approximate 8 mg of aspirin, take 400 mg to 800 mg of willow bark extract
• To approximate 11 mg of aspirin, take 500 mg to 1 gram of willow bark extract

4. Strengthen hormone balance and vitamin D support. Our hormones set the tone for how our body handles stress and illness. Vitamin D helps our body make a special protein that boosts immune function. Natural hormones like progesterone, along with tools that lower stress hormones such as cortisol, protect against damage caused by constant stress.

Research in prostate cancer models has even shown that supporting male hormones while lowering oestrogen shrinks tumours, challenging long-standing medical beliefs. Getting regular sunlight and maintaining healthy vitamin D levels is a simple way to strengthen this system. You can track your progress by keeping tabs on sleep quality and calm focus.

5. Calm your gut and lower stress signals. Digestive health plays a major role in controlling inflammation throughout your body. When our gut is out of balance, it produces endotoxins that keep stress signals elevated and disrupt normal repair. This often shows up as bloating, irregular bowel movements, or poor sleep.

Keeping your carbohydrate intake steady with easy-to-digest options like fresh fruit and basmati rice is also key. When carbs are too low or inconsistent, your body shifts into stress mode and burns fat in ways that damage metabolism. By focusing on digestion and steady fuel, you create a healthier rhythm that reduces stress signals and lowers the burden of inflammation.

FAQs about metabolic health, inflammation, and cancer risk

Q: How are inflammation and metabolism linked to cancer risk?

A: Chronic inflammation keeps our body in a constant state of damage and repair, which weakens immunity and allows tumours to grow. At the same time, when our cells can’t burn glucose efficiently, they fall back on a less effective energy process (glycolysis) that cancer cells exploit. This combination – high inflammation and broken metabolism – creates the perfect environment for cancer to progress.

Q: What role do stress hormones play in tumour growth?

A: Cortisol, our main stress hormone, briefly lowers inflammation but also floods our blood with fatty acids and blocks glucose from being used properly. This forces cells into glycolysis, producing lactic acid and fuelling tumour growth. High stress means our body is stuck in this harmful cycle, leaving cancer cells with the advantage.

Q: How did B vitamins and aspirin impact tumours in research?

A: In mouse models, a combination of vitamins B1, B3, and B7 stopped tumour growth, creating a state of remission. When aspirin was added to the mix, tumours didn’t just stop growing – they disappeared completely and did not return after treatment ended. The human-equivalent aspirin dose was around to 1.2 grams daily. Natural alternatives can be used.

Q: Are hormones like testosterone really dangerous in prostate cancer?

A: Contrary to the common belief that testosterone fuels prostate cancer, Dinkov shared evidence that supporting male hormones while lowering oestrogen actually shrank prostate tumours. This challenges mainstream dogma and points to hormone balancing – not suppression – as a promising treatment path.

Q: What simple steps lower inflammation and support clean energy?

A: Practical strategies include: rebuilding glucose metabolism with vitamins B1, B3, and B7; adding aspirin or willow bark; supporting vitamin D and natural progesterone; avoiding refined seed oils while adding protective compounds like molecular hydrogen; and improving gut health with balanced carbs. Each of these supports cleaner energy, steadier metabolism, and fewer inflammatory signals that cancer cells rely on.

Analysis by Dr. Joseph Mercola

 

yogaesoteric
January 26, 2026