First Case of Covid Vax-Derived Genetic Material Found in Human

A scientific study just published on Zenodo presents the first documented evidence of genomic integration of mRNA vaccine-derived genetic material in a human subject

The case involves a previously healthy 31-year-old woman who developed rapidly progressive stage IV bladder cancer within 12 months of completing a three-dose Moderna vaccination series.

Key Findings

Aggressive cancer following vaccination

A previously healthy young woman, received three Moderna vaccine doses in May, June, and December 2021. Within about a year, she was diagnosed with rapidly progressing stage IV bladder cancer. *Bladder cancer is rare in young women.

Dysregulation of cancer driver genes

Multi-omic profiling of her blood, plasma, and urine exosomes revealed dysregulated expression and signalling in multiple cancer driver genes. These included oncogenes (KRAS, NRAS, PIK3CA, MAPK1) and DNA repair/tumour suppressor genes (ATM, CHD4, SF3B1). This pattern demonstrates genome instability and impaired DNA repair mechanisms.

Vaccine sequence detected in DNA

• The study detected a host–vector chimeric read – a short DNA fragment that contains both human DNA and a piece of the spike protein sequence identical to the covid-19 vaccine sequence. The sequence matches a Pfizer reference, because Moderna’s exact plasmid sequence (used in the vaccine) is not publicly available.
• The sequence contained a 20-base exact match with part of the spike open reading frame used in covid-19 mRNA vaccine constructs. *The spike open reading frames are broadly similar across mRNA vaccine platforms.
• The probability of a random 20-base sequence perfectly matching a predefined target is approximately 1 in a trillion, making the alignment statistically compelling and ruling out incidental artifact.
• This fragment was found on chromosome 19 (region 19q13.42), outside the canonical AAVS1 “safe harbour” and within a gene-dense, recombination-prone regulatory region. This location carries risk of transcriptional disruption, fusion transcript formation, and oncogenic potential.
• This represents a genomic integration event.

Authors’ Interpretation

This is the first documented case of vaccine-derived sequences integrated into human DNA.

The integration site lies outside safe harbour regions, meaning it disrupts normal gene regulation.

The findings are described as “biologically plausible” and “highly unusual.”

The authors call for urgent follow-up studies, including:

• Long-read sequencing to verify the integration event.
• Genomic surveillance in vaccinated persons.
• Large-scale research into the effects of synthetic mRNA vaccine platforms on genome integrity and cancer risk.

I also want to point out that this finding reinforces why vaccinated people should not donate blood.

Conclusion

This case report shows that mRNA vaccine sequences became integrated into the genome of a cancer patient, along with major disruptions in key genes.

The evidence makes it clear that all covid-19 mRNA vaccines should be immediately withdrawn from the market. Humanity now faces an unprecedented risk of vaccine-induced changes to the genome – a danger that cannot be ignored.

Key Terms Explained

• Genome – the complete set of DNA in a person’s cells, containing all genetic information.
• Cancer driver genes – genes that, when mutated or dysregulated, directly contribute to cancer. These can include oncogenes (promote cell growth when overactive) and tumour suppressors/DNA repair genes (protect against cancer but increase risk when impaired).
• DNA repair genes – genes that detect and repair DNA damage; if disrupted, errors accumulate and may lead to cancer.
• Exosomes – tiny particles released by cells that carry proteins and genetic material; often studied as biomarkers.
• Multi-omic profiling – combining several molecular methods (DNA, RNA, protein analysis) to get a detailed view of what is going on in cells.
• Chimeric read – a short DNA sequence showing features of two different origins, here human DNA plus a vaccine-derived sequence.
• Genomic integration – when foreign genetic material becomes inserted into the cell’s own DNA.
• Safe harbour region – areas of the genome where inserted DNA is unlikely to interfere with essential genes. Integration outside these regions may disrupt normal function.
• Long-read sequencing – an advanced technique that reads very long DNA fragments, making it easier to confirm whether integration truly occurred.

Author: Dr. Lidiya Angelova

yogaesoteric
October 4, 2025